| By Kate Kelland and Ben Hirschler (Reuters) - A new
superbug could spread around the world after reaching Britain from
India -- in part because of medical tourism -- and scientists say
there are almost no drugs to treat it.
Researchers said on Wednesday they had found a new gene called New
Delhi metallo-beta-lactamase, or NDM-1, in patients in South Asia
and in Britain.
NDM-1 makes bacteria highly resistant to almost all antibiotics,
including the most powerful class called carbapenems, and experts
say there are no new drugs on the horizon to tackle it.
With international travel in search of cheaper healthcare
increasing, particularly for procedures such as cosmetic surgery,
Timothy Walsh, who led the study, said he feared the new superbug
could soon spread across the globe.
"At a global level, this is a real concern," Walsh, from Britain's
Cardiff University, said in telephone interview.
"Because of medical tourism and international travel in general,
resistance to these types of bacteria has the potential to spread
around the world very, very quickly. And there is nothing in the
(drug development) pipeline to tackle it."
Almost as soon as the first antibiotic penicillin was introduced in
the 1940s, bacteria began to develop resistance to its effects,
prompting researchers to develop many new generations of
antibiotics.
But their overuse and misuse have helped fuel the rise of
drug-resistant "superbug" infections like methicillin-resistant
Staphyloccus aureus (MRSA).
In a study published in The Lancet Infectious Diseases journal on
Wednesday, Walsh's team found that NDM-1 is becoming more common in
Bangladesh, India, and Pakistan and is also being imported back to
Britain in patients returning after treatment.
"India also provides cosmetic surgery for other Europeans and
Americans, and it is likely NDM-1 will spread worldwide," the
scientists wrote in the study.
"CINDERELLA" BUSINESS
For many years, antibiotic research has been a "Cinderella" sector
of the pharmaceuticals industry, reflecting a mismatch between the
scientific difficulty of finding treatments and the modest sales
such products are likely to generate, since new drugs are typically
saved only for the sickest patients.
But the increasing threat from superbugs is encouraging a rethink at
the few large drugmakers still actively hunting for new antibiotics,
including Pfizer, Merck, AstraZeneca, GlaxoSmithKline and Novartis.
Walsh and his international team collected bacteria samples from
hospital patients in two places in India, Chennai and Haryana, and
from patients referred to Britain's national reference laboratory
between 2007 and 2009.
They found 44 NDM-1-positive bacteria in Chennai, 26 in Haryana, 37
in Britain, and 73 in other sites in Bangladesh, India, and
Pakistan. Several of the British NDM-1 positive patients had
recently traveled to India or Pakistan for hospital treatment,
including cosmetic surgery, they said.
Most worryingly, NDM-1-producing bacteria are resistant to many
antibiotics including carbapenems, the scientists said, a class of
the drugs often reserved for emergency use and to treat infections
caused by other multi-resistant bugs like MRSA and C-Difficile.
Anders Ekblom, global head of medicines development at AstraZeneca,
whose Merrem antibiotic is the leading carbapenem, said he saw
"great value" in investing in new antibiotics.
"We've long recognized the growing need for new antibiotics, he
said. "Bacteria are continually developing resistance to our arsenal
of antibiotics and NDM1 is just the latest example."
Experts commenting on Walsh's findings said it was important to be
alert to the new bug and start screening for it early.
"If this emerging public health threat is ignored, sooner or later
the medical community could be confronted with carbapenem-resistant
(bacteria) that cause common infections, resulting in treatment
failures with substantial increases in health-care costs," Johann
Pitout from the University of Calgary in Canada wrote in a
commentary in same journal.
(Editing by Myra MacDonald)
Well, your mother told you this would
happen if you didn't wash your face and hands and use soap.
In the U.S. we have the perfect petri dish waiting for this
bacteria to show up. We've used and abused the existing stock of
antibiotics to the point that we're breeding only antibiotic
resistant bacteria. The government has set up dis-incentives for the
drug companies to produce new antibiotics - no money to be made
there. The hospitals are dirty, staffed by minimum-wage
affirmative-action zombies. There are not enough old-fashioned
family doctors, everyone is a high priced specialist. And then we
have obamacare.
Better hope that this super-bug story is just another scare story
like swine flu. But what are we going to do when something bad
really starts spreading?

Super-Bug (Artist's Depiction)
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